An Ultrasound-Guided Platform
to Advance Your Biomedical
Research 
in Focused Ultrasound

Verasonics, in collaboration with Sonic Concepts, Inc., an innovator of high performance transducers are introducing the HIFUPlex Portfolio. By bringing together the best of Sonic Concepts’ transducers, and the high quality and flexibility of Verasonics’ Vantage ultrasound systems, the HIFUPlex portfolio delivers premium quality, innovation and versatility to ultrasound-guided focused ultrasound (USgFUS). HIFUPlex addresses many applications in focused ultrasound (FUS), and meets a wide range of budgets.

Sonic Concepts designs and manufactures cutting-edge, top-of-the-line therapeutic transducers in many different configurations. These transducers offer high efficiency over a broad bandwidth and highly uniform acoustic output at the radiating surface ideal for FUS applications. Verasonics’ Vantage ultrasound systems are used today at numerous institutions and companies worldwide for FUS research and product development. The Vantage 64LE, Vantage 128 and Vantage 256 systems are available in high intensity focused ultrasound (HIFU) configurations, which enable both energy delivery and imaging using the same transmitters, for flexible and comprehensive exploration with focused ultrasound.

Focused ultrasound is becoming increasingly preferred as a valuable non-invasive therapeutic technology in a variety of clinical areas including cardiology, endocrinology, oncology and women’s health. HIFUPlex can be used in most of these areas to advance biomedical research. FUS demonstrates important and growing utility in a variety of application areas, using a range of modalities such as tissue destruction, drug delivery, neuro-stimulation and modulation, immunomodulation and stem cell honing. MRI has predominantly been used to guide FUS, however researchers today are developing ultrasound-guided FUS (USgFUS) applications because they are more flexible and less costly. Ultrasound is ideal not only for energy delivery, but also to identify, guide and target tissue in real time, as well as to monitor the treatment.

Read about the Collaboration Between Verasonics and Sonic Concepts
HIFUPlex Press Release

Introducing the HIFUPlex Portfolio

HIFUPlex offers:

  • Five standard ultrasound system and transducer configurations to meet a range of customer requirements, including variable depths and frequencies, for research and development
  • An easy upgrade pathway from any Vantage configuration and from non USgFUS solutions using Sonics Concepts’ Transducer Power Output™ (TPO™) system
  • A graphical user interface (GUI), with interleaving scripts that control the major parameters of FUS and imaging

Vantage USgFUS GUI:

The Vantage software combined with HIFUPlex now includes a GUI, with interleaving scripts that control the major parameters of FUS and imaging. The Vantage USgFUS GUI is included in the 3D USgFUS and 1D USgFUS HIFUPlex Portfolio configurations.

Software: Full-screen graphical user interface for visualization and control

  • Provides high-level selection of modular operating modes
  • Includes operating modes for typical USgFUS experimental workflow
  • Extensible Modes Include:
    – Imaging only (B-mode, color flow Doppler)
    – FUS only (adjust pulse frequency, duration, voltage, focal position)
    – GUI-based treatment protocol design and preview
    – Test utilities

HIFUPlex Portfolio Configurations:

3D USgFUS:

Solutions for large animal and deep target applications with 3D FUS focal positioning and 2D imaging

HIFUPlex-04 & -05 (0.5 & 2.0 MHz, respectively) provide 3D therapeutic focusing where both lateral and axial steering is required. These solutions provide interleaving capability between the FUS therapy and imaging using the Vantage platform.

FUS key features include:

  • Ø150 mm f/1.0 FUS transducer
  • Center frequencies available at 0.5 and 2.0 MHz
  • Transmit efficiencies up to 80% over a 40% bandwidth
  • Axial focal steering between 110 and 140 mm (from the exit plane)
  • Lateral steering Ø12 mm (from the axis)

Imaging features include:

  • 3.5 MHz 128-element phased array
  • Watertight housing with rotational and vertical adjustability

1D USgFUS:

Solutions for small animal and intermediate depths, with adjustable FUS focal depth and 2D imaging

HIFUPlex-01, -02 & -03 (0.5, 1.1 & 2.0 MHz, respectively) provide 1D therapeutic focusing on small and large animals under ultrasound guidance. These solutions provide interleaving capability between the FUS therapy and imaging using the Vantage platform.

FUS key features include:

  • Ø64 mm f/1.0 FUS transducer
  • Center frequencies available at 0.5, 1.1 and 2.0 MHz
  • Transmit efficiencies up to 90% over a 40% bandwidth
  • Axial focal steering (25 to 75 mm from the transducer exit plane)

Imaging features include:

  • 5.0 MHz 64-element phased array
  • Watertight housing with rotational and vertical adjustability

1D FUS:

Solutions without imaging (adjustable FUS focal depth) to initiate research within a conservative budget

HIFUPlex-00 is designed to accommodate superficial to moderate depth investigations with electronic axial steering (from 25 to 75 mm from the transducer exit plane). An example of 500 kHz focal steering is presented below.

FUS key features include:

  • Ø64 mm f/1.0 FUS transducer
  • Center frequencies available at 0.5, 1.1 and 2.0 MHz
  • Transmit efficiencies up to 90% over a 40% bandwidth
  • Axial focal steering from 25 to 75 mm from the transducer plane
  • Transmit drive electronics provide an easy-to-use GUI touch screen offering adjustable calibrated power output, frequency, pulse repetition rate, burst duration, axial steering position and more

NOTE: HIFUPlex-00 is upgradable to HIFUPlex-01, -02 or -03 to add ultrasound imaging for ultrasound-guided FUS (USgFUS).

HIFUPlex Design Specifications:

The selection, development and utilization of transducers for HIFU applications requires special considerations. Learn more here.

Download the HIFUPlex Portfolio and Specifications Brochure
HIFUPlex Brochure
Learn about Vantage System
Transmit Capabilities
Vantage Transmit Options
See a Video Demonstrating 3D HIFU Array With Image Guidance
HIFU Video Demonstration